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Mycobacterium avium complex disease

MedGen UID:
6478
•Concept ID:
C0026916
•
Disease or Syndrome
Synonyms: Infection, Mycobacterium avium intracellulare; Infection, Mycobacterium avium-intracellulare; Infection, Mycobacterium intracellulare; Infections, Mycobacterium avium-intracellulare; Infections, Mycobacterium intracellulare; Mycobacterium avium intracellulare Infection; Mycobacterium avium-intracellulare Infection; Mycobacterium avium-intracellulare Infections; Mycobacterium intracellulare Infection; Mycobacterium intracellulare Infections
SNOMED CT: Infection caused by Mycobacterium intracellulare (373436002)
 
Monarch Initiative: MONDO:0005866

Definition

An infection that is caused by Mycobacterium avium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMycobacterium avium complex disease

Professional guidelines

PubMed

Impact of chronic co-infection in pulmonary Mycobacterium avium complex disease after treatment initiation.
Urabe N, Sakamoto S, Shimanuki Y, Kanokogi T, Motohashi T, Anzai N, Kato C, Yamaguchi A, Tokita N, Homma S, Kishi K
BMC Pulm Med 2022 Apr 25;22(1):157. doi: 10.1186/s12890-022-01947-7. PMID: 35468795Free PMC Article
Nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex - disease burden, unmet needs, and advances in treatment developments.
van Ingen J, Obradovic M, Hassan M, Lesher B, Hart E, Chatterjee A, Daley CL
Expert Rev Respir Med 2021 Nov;15(11):1387-1401. Epub 2021 Oct 18 doi: 10.1080/17476348.2021.1987891. PMID: 34612115
Rifabutin for infusion (BV100) for the treatment of severe carbapenem-resistant Acinetobacter baumannii infections.
Trebosc V, Kemmer C, Lociuro S, Gitzinger M, Dale GE
Drug Discov Today 2021 Sep;26(9):2099-2104. Epub 2021 Jul 6 doi: 10.1016/j.drudis.2021.07.001. PMID: 34242796

Recent clinical studies

Etiology

Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis.
Yamashita Y, Yasuda I, Tanaka T, Ikeda T, Terada M, Takaki M, Tsuchihashi Y, Asoh N, Ohara Y, Enany S, Kobayashi H, Matsumoto S, Morimoto K
Front Immunol 2023;14:1222428. Epub 2023 Jul 14 doi: 10.3389/fimmu.2023.1222428. PMID: 37520555Free PMC Article
Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease.
Henkle E, Quittner AL, Dieckmann NF, Franklin H, Brunton AE, Daley CL, Winthrop KL; MAC2v3 Investigators
Chest 2023 Jul;164(1):53-64. Epub 2023 Feb 17 doi: 10.1016/j.chest.2023.02.015. PMID: 36803647Free PMC Article
Impact of chronic co-infection in pulmonary Mycobacterium avium complex disease after treatment initiation.
Urabe N, Sakamoto S, Shimanuki Y, Kanokogi T, Motohashi T, Anzai N, Kato C, Yamaguchi A, Tokita N, Homma S, Kishi K
BMC Pulm Med 2022 Apr 25;22(1):157. doi: 10.1186/s12890-022-01947-7. PMID: 35468795Free PMC Article
Nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex - disease burden, unmet needs, and advances in treatment developments.
van Ingen J, Obradovic M, Hassan M, Lesher B, Hart E, Chatterjee A, Daley CL
Expert Rev Respir Med 2021 Nov;15(11):1387-1401. Epub 2021 Oct 18 doi: 10.1080/17476348.2021.1987891. PMID: 34612115
Mycobacterium avium Complex Disease.
Daley CL
Microbiol Spectr 2017 Apr;5(2) doi: 10.1128/microbiolspec.TNMI7-0045-2017. PMID: 28429679

Diagnosis

Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis.
Yamashita Y, Yasuda I, Tanaka T, Ikeda T, Terada M, Takaki M, Tsuchihashi Y, Asoh N, Ohara Y, Enany S, Kobayashi H, Matsumoto S, Morimoto K
Front Immunol 2023;14:1222428. Epub 2023 Jul 14 doi: 10.3389/fimmu.2023.1222428. PMID: 37520555Free PMC Article
Nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex - disease burden, unmet needs, and advances in treatment developments.
van Ingen J, Obradovic M, Hassan M, Lesher B, Hart E, Chatterjee A, Daley CL
Expert Rev Respir Med 2021 Nov;15(11):1387-1401. Epub 2021 Oct 18 doi: 10.1080/17476348.2021.1987891. PMID: 34612115
Mycobacterium avium Complex Disease.
Daley CL
Microbiol Spectr 2017 Apr;5(2) doi: 10.1128/microbiolspec.TNMI7-0045-2017. PMID: 28429679
Serodiagnosis of Mycobacterium avium complex disease in humans: translational research from basic mycobacteriology to clinical medicine.
Kobayashi K
Jpn J Infect Dis 2014;67(5):329-32. doi: 10.7883/yoken.67.329. PMID: 25241680
Mycobacterium avium complex pulmonary disease in immunocompetent patients.
Chitty SA, Ali J
South Med J 2005 Jun;98(6):646-52. doi: 10.1097/01.SMJ.0000154311.60057.56. PMID: 16004172

Therapy

Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis.
Yamashita Y, Yasuda I, Tanaka T, Ikeda T, Terada M, Takaki M, Tsuchihashi Y, Asoh N, Ohara Y, Enany S, Kobayashi H, Matsumoto S, Morimoto K
Front Immunol 2023;14:1222428. Epub 2023 Jul 14 doi: 10.3389/fimmu.2023.1222428. PMID: 37520555Free PMC Article
Monotherapy: Key cause of macrolide-resistant Mycobacterium avium complex disease.
Loewenstein D, van Balveren L, Lemson A, Hanemaaijer N, Hoefsloot W, van Ingen J
Respir Med 2023 Oct;217:107366. Epub 2023 Jul 20 doi: 10.1016/j.rmed.2023.107366. PMID: 37481170
Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease.
Henkle E, Quittner AL, Dieckmann NF, Franklin H, Brunton AE, Daley CL, Winthrop KL; MAC2v3 Investigators
Chest 2023 Jul;164(1):53-64. Epub 2023 Feb 17 doi: 10.1016/j.chest.2023.02.015. PMID: 36803647Free PMC Article
Mycobacterium avium Complex Disease.
Daley CL
Microbiol Spectr 2017 Apr;5(2) doi: 10.1128/microbiolspec.TNMI7-0045-2017. PMID: 28429679
Mycobacterium avium complex pulmonary disease in immunocompetent patients.
Chitty SA, Ali J
South Med J 2005 Jun;98(6):646-52. doi: 10.1097/01.SMJ.0000154311.60057.56. PMID: 16004172

Prognosis

Analysis of adverse drug events in pulmonary Mycobacterium avium complex disease using spontaneous reporting system.
Ozawa T, Namkoong H, Takaya R, Takahashi Y, Fukunaga K, Enoki Y, Taguchi K, Kizu J, Matsumoto K, Hasegawa N
BMC Infect Dis 2022 Jun 29;22(1):580. doi: 10.1186/s12879-022-07568-z. PMID: 35768763Free PMC Article
Comparison of clinical characteristics of patients with Mycobacterium avium complex disease by gender.
Ikuyama Y, Ushiki A, Akahane J, Kosaka M, Kitaguchi Y, Urushihata K, Yasuo M, Yamamoto H, Hanaoka M
Epidemiol Infect 2019 Jan;147:e108. doi: 10.1017/S0950268819000293. PMID: 30869034Free PMC Article
Clinical characteristics and early outcomes of patients newly diagnosed with pulmonary Mycobacterium avium complex disease.
Hagiwara E, Katano T, Isomoto K, Otoshi R, Yamakawa H, Okuda R, Sekine A, Baba T, Komatsu S, Ogura T
Respir Investig 2019 Jan;57(1):54-59. Epub 2018 Oct 24 doi: 10.1016/j.resinv.2018.08.006. PMID: 30366835
Opinions differ by expertise in Mycobacterium avium complex disease.
Marras TK, Prevots DR, Jamieson FB, Winthrop KL; Pulmonary MAC Outcomes Group
Ann Am Thorac Soc 2014 Jan;11(1):17-22. doi: 10.1513/AnnalsATS.201305-136OC. PMID: 24083335Free PMC Article
Preventing disseminated Mycobacterium avium complex disease in patients infected with human immunodeficiency virus.
Ostroff SM, Spiegel RA, Feinberg J, Benson CA, Horsburgh CR Jr
Clin Infect Dis 1995 Aug;21 Suppl 1:S72-6. doi: 10.1093/clinids/21.supplement_1.s72. PMID: 8547516

Clinical prediction guides

Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis.
Yamashita Y, Yasuda I, Tanaka T, Ikeda T, Terada M, Takaki M, Tsuchihashi Y, Asoh N, Ohara Y, Enany S, Kobayashi H, Matsumoto S, Morimoto K
Front Immunol 2023;14:1222428. Epub 2023 Jul 14 doi: 10.3389/fimmu.2023.1222428. PMID: 37520555Free PMC Article
Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease.
Henkle E, Quittner AL, Dieckmann NF, Franklin H, Brunton AE, Daley CL, Winthrop KL; MAC2v3 Investigators
Chest 2023 Jul;164(1):53-64. Epub 2023 Feb 17 doi: 10.1016/j.chest.2023.02.015. PMID: 36803647Free PMC Article
Impact of chronic co-infection in pulmonary Mycobacterium avium complex disease after treatment initiation.
Urabe N, Sakamoto S, Shimanuki Y, Kanokogi T, Motohashi T, Anzai N, Kato C, Yamaguchi A, Tokita N, Homma S, Kishi K
BMC Pulm Med 2022 Apr 25;22(1):157. doi: 10.1186/s12890-022-01947-7. PMID: 35468795Free PMC Article
Pneumonectomy for nontuberculous mycobacterial infections.
Shiraishi Y, Nakajima Y, Katsuragi N, Kurai M, Takahashi N
Ann Thorac Surg 2004 Aug;78(2):399-403. doi: 10.1016/j.athoracsur.2004.02.103. PMID: 15276484
Disseminated Mycobacterium avium complex disease in patients with AIDS.
Benson C
AIDS Res Hum Retroviruses 1994 Aug;10(8):913-6. doi: 10.1089/aid.1994.10.913. PMID: 7811542

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